The binding of all seven anti-HER3 mAbs was significantly reduced by HER3-KD in LS-LM4 [29, 30] cells originated from LS-174T cells (Figure 2A), and almost completely diminished by HER3-KO in SW1116 cells (Figure 2B), demonstrating the accurate specificity of seven mAbs against native HER3 proteins on living cancer cells. Here, ERBB3 is linked to cancer.