For example, upregulated VEGF-C and VEGF-D secretion by cancer cells have been shown to induce preferential lymphatic metastasis via LEC VEGFR-2 and VEGFR-3, whereas blood endothelial cell (BEC) angiogenesis prefers VEGF-A/VEGFR-1 signaling. The gene discussed is VEGFC; the disease is cancer.