Then the expression profiles of the five genes between tumor and normal tissue shown in Fig. 3E which indicated that PADI1 was significantly upregulated in ccRCC while ATP6V0D2, DPP6, C9orf135 and PLG were significantly downregulated when compared with normal tissue (p < 0.001). The gene discussed is ATP6V0D2; the disease is nonpapillary renal cell carcinoma.