Then the expression profiles of the five genes between tumor and normal tissue shown in Fig. 3E which indicated that PADI1 was significantly upregulated in ccRCC while ATP6V0D2, DPP6, C9orf135 and PLG were significantly downregulated when compared with normal tissue (p < 0.001). This evidence concerns the gene CFAP95 and nonpapillary renal cell carcinoma.