ALOX5 and asthma: 5-HpETE is further metabolized to leukotrienes by leukotriene-converting enzymes and leukotrienes exert physiological functions in the pathophysiology of asthma and inflammation.(35) Additionally, there is another 5-LOX associated arachidonate-derived metabolite: lipoxin A4.(36) It is possible that daidzein-induced enzymatic activation of 5-LOX produced 5-LOX-associated PUFA-derived metabolites other than 5-HpETE and that these metabolites exert antiviral activity.