Metformin and EPA decrease SeP mRNA expression.(61,64) However, these diabetes drugs are not effective against PAH-PASMC proliferation, which suggests other molecular mechanisms that increase SeP expression in PAH.(77) To inhibit the SeP expression in PAH-PASMCs, sanguinarine, a plant alkaloid, has been identified by high-throughput screening of 3,336 compounds. This evidence concerns the gene SELENOP and pulmonary arterial hypertension.