SELENOP and pulmonary arterial hypertension: Recently, it has been described that the increased expression of SeP in pulmonary artery smooth muscle cells (PASMCs) forming lesions of pulmonary arterial hypertension (PAH).(77) PAH-PASMCs are proliferative compared with normal PASMCs, and the pulmonary artery is constricted/occluded by abnormal proliferation of PAH-PASMCs, which induces PAH with right heart failure.