SeP-neutralizing antibodies are effective against diabetes in model mice, such as KKAy mice and mice fed with a high fat and high sucrose diet, in which SeP levels are increased.(18) In addition to improved insulin resistance and insulin secretion, SeP-neutralizing antibodies significantly decreased total cholesterol and triglycerides in the liver of KKAy mice, indicating the diverse beneficial effects of SeP-targeting reagents. Here, INS is linked to diabetes mellitus.