GATA3 and lipoid nephrosis: Notably, the transcription level of GATA-binding protein 3 (GATA-3), a master regulator of Th2 differentiation and transcriptional activator of Th2 cytokines, such as interleukins (IL) 4, 5, and 1310,11, was significantly upregulated in peripheral blood mononuclear cells (PBMCs) from MCNS patients in the nephrotic state compared with remission state1.