In this regard, the molecular insights obtained in our study remain inconclusive: while transient induction of cell cycle arrest protects actively cycling cells from entering mitosis at non-permissive temperatures, which would otherwise lead to effective cell killing through mitotic catastrophe, the observed hyperaccumulation at temperatures above 41 °C degrees suggests that p53 wild-type cancer cells may be susceptible to increased induction of apoptosis or senescence under these conditions. This evidence concerns the gene TP53 and cancer.