On the other hand, when monocytes prepared from bone marrow cells were co-cultured with LLC tumor cells, we observed upregulation of the activation markers CD86, MHC class II and CD206 in control monocytes-derived macrophages, and this upregulation was impaired in Frount-deficient macrophages (Fig. 4c), suggesting that FROUNT mediates tumor-cell dependent activation of monocytes/macrophages. Here, MRC1 is linked to neoplasm.