In FROUNT-GFP reporter (Frount-gfp knock-in) mice (Supplementary Fig. 5a–d), FROUNT expression was much higher in both Ly-6Chi and Ly-6Clo monocytes/macrophages than in other leukocyte subsets in tumor tissue, as well as in the bone marrow, which is a major source of tumor-associated macrophages21 (Fig. 3a and Supplementary Fig. 5e). The gene discussed is NUP85; the disease is neoplasm.