Interestingly, one FROUNT inhibitor identified through multi-step screening of a library of 131,200 low-molecular weight compounds (Supplementary Fig. 8) was disulfiram (DSF), a known aldehyde dehydrogenase (ALDH) inhibitor and a clinically safe drug that has been in use for the treatment for alcoholism for over 60 years26. Here, LDHA is linked to alcohol dependence.