With nanoinhibitors as treatments on TMZ-resistant glioma cells, BIP-MPC-NP simultaneously attenuated p-EGFR and p-MET in cells with EGF and HGF incubation (Supplementary Fig. 7b) or without EGF and HGF incubation (Fig. 3a), and this attenuation was more significant than that of EBP-MPC-NP or MBP-MPC-NP group. This evidence concerns the gene EGFR and central nervous system cancer.