The coactivation of receptor tyrosine kinase (RTK) proteins, including insulin-like growth factor receptor (IGFR), hepatocyte growth factor receptor (HGFR; also known as MET), fibroblast growth factor receptor (FGFR), vascular endothelial growth factor receptor (VEGFR) and the EGFR family6, acts as an important mechanism by which cancer cells develop acquired chemoresistance7. The gene discussed is MET; the disease is cancer.