EGFR and central nervous system cancer: To further investigate the genomic aberration involved in the biological process of glioma, we employed The Cancer Genome Atlas (TCGA) copy number variation (CNV) datasets of glioma and found that amplification events of chromosome 7 were the major alteration in glioma, and the amplification of EGFR and MET gene copy numbers were the top two RTK gene variations on chromosome 7 in both lower grade glioma (LGG) and GBM (Supplementary Fig. 1a, b, Supplementary Data 1).