These data point to a broad IFN-γ-induced genetic program induced in WT but not IFNγR2- or Jak1-mutant tumor cells early in the antitumor immune response, with most of these genes being positive factors for antitumor immunity, but the key negative regulator PD-L1 is also induced in WT tumor cells yet lost in IFNγR signaling mutants. Here, CD274 is linked to neoplasm.