SUZ12 and Behcet disease: Suppressor Of Zeste12 Protein Homolog (SUZ12), an essential scaffolding component of PRC2 reported to associated with EZH1, also relocated to activated BD genes, which together with the evident of reduced EZH2 deposition suggested an atypical PRC2 complex mainly consisted of EZH1 and SUZ12, initially discovered within hematopoietic and heart cells, relocated to and elicited the bdDEG gene activation (Supplementary Fig. 3c–e)15,16.