For example, CCR7, a known regulator of T-lymphocyte migration, is necessary and sufficient to drive infiltration of T-ALL cells into the CNS in a mouse model45 and inhibition of CXCR3, another lymphocyte migratory factor, significantly reduced leukemic infiltration into bone marrow, spleen and CNS46. The gene discussed is CXCR3; the disease is acute lymphoblastic leukemia.