Our RPPA analyses determined that the expression of other proteins were affected by PRL-3, including Histone-H3, Chk2, JNK, Hes1, Rictor, Axl, and Hif1-alpha, all of which play known roles in tumor progression, and may represent novel mechanisms by which PRL-3 promotes T-ALL. This evidence concerns the gene PTP4A3 and T-cell acute lymphoblastic leukemia.