Similarly, when we overexpressed PRL-3 in Jurkat and HBP-ALL cells (Supplemental Fig. 5A), we found no significant difference in cell growth (Supplemental Fig. 5B), but significantly enhanced migratory capability compared to control (p ≤ 0.009, Supplemental Fig. 5C). This evidence concerns the gene PTP4A3 and acute lymphoblastic leukemia.