Improved effector functions have also been reported following PDCD1 gene editing in virus-specific cytotoxic T lymphocytes (CTL)23 24 and in myeloma-specific CTL.25 In melanoma, the superior antitumor efficacy of PDCD1-edited human-specific CTL has not been formally documented so far. The gene discussed is PDCD1; the disease is plasma cell myeloma.