As expected, we obtained similar results with the wild-type and the PD-L1 expressing melanoma cell lines (figure 5B), namely that IFN-γ and IL-2 production were decreased on activation of WT4 T cell clone by PD-L1 expressing melanoma cells (left panel, dotted lines), compared with non-expressing ones (solid lines), whereas the expression of PD-L1 by melanoma cells did not alter IFN-γ and IL-2 production by KO6 T cell clone (figure 5B, right panel). The gene discussed is CD274; the disease is melanoma.