Suppression of WWOX expression by small interfering RNA induces Tau hyperphosphorylation and formation of neurofibrillary tangles in neuroblastoma SK-N-SH cells, suggesting a crucial role of WWOX in inhibiting Tau phosphorylation in the degenerative neurons of Alzheimer’s disease [15, 58, 59]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.