Furthermore, as the rescue experiments shown, siATOH8 partially reversed VEGF-induced upregulation of HK2 activity and ATOH8, HK2, and BCL2/BAX ratio (Fig. 4k, Additional file 3: Figure S7 h) and restored VEGF-induced reduction of ROS production and anoikis (Additional file 3: Figure S7i-j) in suspended CRC cells. This evidence concerns the gene VEGFA and colorectal carcinoma.