AKT1 and colorectal carcinoma: Mechanismly, ATOH8 was upregulated in CRC m-CTCs via the VEGF-VEGFR2-AKT signalling pathways triggered by LSS, consequently mediating m-CTC survival by primarily promoting HK2 transcriptional activity, which is of great significance for the effective prediction of tumour metastasis or the search for new CTC therapeutic targets.