Herein, a series of bioinformatics analyses were performed on four independent gene chip databases (from cirrhotic and liver cancer tissue), and 58 common DEGs were identified, of which 12 and 46 were up- and down-regulated, respectively. Among the DEGs, three potential hub genes (CDKN3, CYP2C9 and LCAT) were obtained using the MCODE plug-in of Cytoscape. The gene discussed is CYP2C9; the disease is liver cancer.