In a rat cerebral ischemia/reperfusion model, it is reported that both CXCR-4 and CXCR-7 receptors were co-expressed in bone marrow-derived MSCs and synergistically promoted their migration even though the effect of CXCR-7 was stronger than that of CXCR-4. This evidence concerns the gene ACKR3 and Cerebral ischemia.