It binds to the surfaces of tumor cells via integrin-binding β4 (ITGB4) and activates the protein kinase/GSK3β signaling pathway, thereby inducing the transcriptional repression of SNAI1. SNAI1 regulates SIRT3, epithelial-mesenchymal transition-related genes, and glucose metabolism and promotes lymphatic metastasis. The gene discussed is SNAI1; the disease is neoplasm.