In the diffuse large B-cell lymphoma, loss of cytoplasmic PTEN was associated with TP53 mutations higher PTEN-targeting microRNA expression and lower mean level of PD-L1 expression whereas PTEN deletion/mutation and expression of p-AKT, PI3K, or nucleoplasmic-PTEN had no association with PD-L1 expression [11]. This evidence concerns the gene PTEN and diffuse large B-cell lymphoma.