Due to the multiple roles of inflammation in osteosarcoma, a series of inflammation-based biomarkers and hematological indices were recommended as prognostic or predictive biomarkers, including CRP, Glasgow prognostic score (GPS), modified Glasgow prognostic score (mGPS), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), neutrophil-to-platelet score (NPS), mean platelet volume-to-plateletcrit ratio (MPV/PCT), etc. [22–26]. The gene discussed is CRP; the disease is osteosarcoma.