The second frameshift variant, c.851_855delCAGAG (Fig. 1), was found in a 62 year old female BC patient with human epidermal growth factor receptor-2 (HER2) negative invasive ductal carcinoma with Ki67 index 32% and it result in a coding change from Threonine to Arginine at the site of deletion and other downstream amino acid encoding changes, plus a premature stop codon at position 302. Here, ERBB2 is linked to breast cancer.