However, in 71 aggressive tumors (high HG and high Ki-67), frequent relapse after flap reconstruction was seen especially in HR-positive breast cancers (HR-positive: p = 0.008; HR-positive/HER2-negative: p = 0.002), which accounts for majority of our study population (Fig. 3e-f). The gene discussed is ERBB2; the disease is breast carcinoma.