In addition, we found that high SNHG6 expression was a powerful prognostic marker for shorter OS in patients with digestive system cancer (HR = 2.49, 95% CI = 1.84–3.36, P < 0.001), glioma (HR = 1.88, 95% CI = 1.14–3.09, P = 0.013) and osteosarcoma (HR = 2.43, 95% CI = 1.30–4.54, P = 0.005), but it was not indicative of other cancers (HR = 1.41, 95% CI = 0.72–2.76, P = 0.319). This evidence concerns the gene SNHG6 and central nervous system cancer.