In Drosophila, Hippo tumor suppressor pathway controls organ size, and proteins such as Yorkie (human homologous Yes Associated Protein 1 -YAP), a transcriptional coactivator, and Hpo and Warts kinases (human homologous Serine/Threonine Kinase 3 -STK3- and Large Tumor Suppressor Kinase 1 -LATS1, respectively) belong to this pathway. The gene discussed is GFER; the disease is neoplasm.