As it is uncertain whether associations between circulating resistin concentrations and adverse cardiac effects may be accounted for by indirect (renal dysfunction or ventricular-vascular coupling) or direct effects, in the present study we assessed the extent to which independent relationships between circulating resistin concentrations and LVM in a large community-based sample are explained by an impact of resistin on renal or aortic function. Here, RETN is linked to Abnormal renal physiology.