BCL6 and diffuse large B-cell lymphoma: The expression of Bcl-6 was nearly 93%; Ki-67 level exceeded 90%; expression of Bcl-2 was all negative; positive rate of C-myc gene was 76.7%.[23] Bcl-2 worked as an oncogene encoding an integral outer mitochondrial membrane protein that decreases the rate of apoptosis,[24] and it was always positive among 50% to 90% of patients with diffuse large B-cell lymphoma.[25]