In addition, SIRT1 is closely related to the activation of NLRP3 inflammasome.71 In rat cerebral ischaemia/reperfusion models and ventilation‐induced lung injury models, SIRT1‐dependent inhibition of NLRP3 inflammatory body activation.72, 73 Therefore, it may be assumed that quercetin effects on DM in db/db mice through SIRT1/NLRP3 signalling pathway. The gene discussed is NLRP3; the disease is diabetes mellitus.