For instance, let‐7 was found to act as a tumour suppressor by targeting HMGA2 in colorectal cancer, in a report by Madison et al.28 Other experiments indicated that H19 promoted pancreatic ductal adenocarcinoma cell invasion and migration by activating let‐7‐mediated HMGA2.29 In the present study, we demonstrated that HMGA2 activated the Wnt/β‐catenin signalling pathway in GBM cells. This evidence concerns the gene HMGA2 and colorectal cancer.