HIPK2 and colorectal cancer: Consistent with our findings, VB was shown to suppress cell proliferation in gastric cancer.32 Hugo et al demonstrated that VB was protective against prostate cancer, acting to reduce the levels of reactive oxygen species in cancer cells.33 Zhou et al similarly found that VB up‐regulated colorectal cancer cell apoptosis by activating the HIPK2‐p53 signalling pathway.25 Notably, our in vitro experiments indicated that VB could down‐regulate PKC, a Wnt pathway‐related gene, by modulating the expression of let‐7g‐5p.