BRCA1 and cancer: Notably, TCGA analysis showed that lower expression of BRCA1 correlates with good prognosis in multiple types of human cancer, including bladder carcinoma, lower-grade glioma, lung adenocarcinoma, pancreatic adenocarcinoma, invasive breast carcinoma, papillary renal cell carcinoma, and head neck squamous cell carcinoma (Figure S6), further supporting the clinical relevance of BRCA1 signaling pathway.