Notably, TCGA analysis showed that lower expression of BRCA1 correlates with good prognosis in multiple types of human cancer, including bladder carcinoma, lower-grade glioma, lung adenocarcinoma, pancreatic adenocarcinoma, invasive breast carcinoma, papillary renal cell carcinoma, and head neck squamous cell carcinoma (Figure S6), further supporting the clinical relevance of BRCA1 signaling pathway. Here, BRCA1 is linked to head and neck squamous cell carcinoma.