BRCA1 and cancer: In contrast, overexpression of truncated CISAL (1-900) in CISAL-silenced cancer cells restored the function of CISAL related to BRCA1 levels (Figure S10G), GABPA/RNA pol II occupancy (Figures 5H, S10H, and S10I), BRCA1 transcriptional activity (Figure 5I), expression of downstream genes (Figures S10J and S10K), as well as mitochondrial fission and cisplatin sensitivity (Figure S10L).