For instance, several antioxidant genes, including SOD2, GST or UCP, have been associated to age-related hearing loss [9] and genetic mouse models deficient for antioxidant genes, including Nrf2 [10,11], Sod1 [12] or genes regulating the mTOR pathway [13], show accelerated age-related hearing loss. Here, SOD2 is linked to presbycusis.