LI-RADS in combination with elevated tumor markers (AFP >100 ng/mL and CA 19-9 >100 U/mL, computed tomography [CT]/MRI LI-RADS® v2018 CORE, https://www.acr.org/Clinical-Resources/Reporting-and-Data-Systems/LI-RADS/CT-MRI-LI-RADS-v2018) could slightly improve diagnostic performance to differentiate HCC from non-HCC malignancies. The gene discussed is AFP; the disease is hepatocellular carcinoma.