Infection of mice with Plasmodium berghei ANKA (PbA) has been used to demonstrate the importance of inflammatory cytokines such as interferon-γ (IFN-γ)[9] and tumor necrosis factor-β, also known as lymphotoxin-α (LT-α)[10], in the development of experimental cerebral malaria (ECM), a disease that shares several key features with human CM[11, 12]. Here, LTA is linked to infection.