However, there was no significant difference in the parasite burden in EphA2-/- and EphA2+/+ mice when assessing the levels of parasites by PbA luciferase expression in the brain (Fig 1C, left, and S1A Fig), parasite mRNA in the brain (Fig 1C, right), or peripheral parasitemia (Fig 1D, top). This evidence concerns the gene EPHA2 and parasitic infectious disease.