Genome-wide association studies (GWAS) have been used to identify the causal mutations for CCD in Finnish Hounds (SEL1L, targeted degradation of misfolded or unassembled peptides), and Old English Sheepdogs and Gordon Setters (RAB24, which has a role in autophagy); and spinocerebellar ataxia in Russell Terrier Group dogs (CAPN1, which encodes μ-calpain, a subunit of calcium dependent cysteine protease) [13–15]. The gene discussed is CAPN1; the disease is cerebellar ataxia.