KCNIP4 and aceruloplasminemia: RT-qPCR analysis did not demonstrate a statistically significant reduction in the expression of the KCNIP4 transcript in the affected Buhunds, although it was suggestive of reduced expression; whereas a dramatic reduction in KCNIP4 protein expression was observed in the cerebellum of cerebellar ataxia-affected Norwegian Buhunds, through both western blot and immunohistochemistry.