CellSearch is the only FDA‐approved CTC enumeration platform and has demonstrated the clinical utility of CTCs in a several cancers,7, 13, 14 however, their utility in non–small cell lung cancer (NSCLC) has been limited by the low expression of EpCAM in CTCs derived from NSCLC patients.15, 16 Lung cancer causes a large number of cancer‐related deaths world‐wide and is often diagnosed at an advanced stage.17 Here, EPCAM is linked to cancer.