ADH1B and cocaine dependence: Data from the Open Targets resource (www.opentargets.org/) suggest that 49 drugs have reached phase IV investigation for DRD2 across a range of indications, including mental health disorders and cocaine dependence; no drugs are in development for ADH1B, KLB, GCKR, or SLC39A8. FGF21 has been explored due to links with KLB, but no drugs are in the market yet.