Although the investigation on the role and mechanism of TRPC6 in DKD podocyte actin cytoskeleton rearrangement is still in its infancy, these results all suggest that it is of great value to study the mechanism of DKD podocyte injury targeting TRPC6 that provide a potential therapeutic target on TRPC6 for DKD. The gene discussed is TRPC6; the disease is diabetic kidney disease.