It is noteworthy that type 1 DKD model Akita mice lacking TRPC6 have only a short-term renal protective effect by inhibiting albuminuria and reducing tubular injury, while mesangial dilatation and insulin resistance subsequently aggravate renal injury, suggesting that LOF-type mutation of TRPC6 has the same pathogenic effect in type 1 DKD [102]. The gene discussed is TRPC6; the disease is Insulin resistance.