To fully determine the potential role of ZBTB7A in the NAFLD, the NASH mouse model was constructed with 16-week high-fat diet, and the ELISA analysis revealed that serum TNFα and IL-6 levels were both upregulated (Figures 3(a) and 3(b)). The gene discussed is ZBTB7A; the disease is metabolic dysfunction-associated steatotic liver disease.