Univariate analysis indicated that tumor topography, lymph node metastasis, and distant metastasis as well as the low expression of CLDN7 (HR = 0.97, 95% CI (0.932–0.990)) (Table 1) were independent risk factors for the overall survival in the patients with ChRCC. This evidence concerns the gene CLDN7 and metastatic malignant neoplasm in the lymph nodes.