After the validation using Oncomine online data, we found that CLDN7, ESRP1, AP1M2, CLDN4, PRSS8, and ZEB1 were differentially expressed between ChRCC and RO (P < 0.05), which were consistent with the results performed by GEO data (Figure 3). Here, PRSS8 is linked to chromophobe renal cell carcinoma.