INS and diabetes mellitus: Glucose is necessary to supply central nervous system with energy [7] and hyperglycemia in diabetes can induce also a variety of complications such as nephropathy, retinopathy, and increased risk of cardiovascular disease [8] that are induced by an injection of streptozotocin (STZ) that selectively destructs insulin-producing β-cells of the pancreas experimentally and leads to brain injury [9].