TARDBP and amyotrophic lateral sclerosis: Motivated by reports that TDP-43 mislocalization from the nucleus to the cytoplasm constitutes an early event in ALS pathogenesis (Giordana et al., 2010), several groups generated disease models based on overexpression of TDP-43 in yeast, worms, flies, fish, and mice (Johnson et al., 2008; Kabashi et al., 2009; Wegorzewska et al., 2009; Liachko et al., 2010; Li et al., 2010).