The compilation of various RNA-seq data sets so far show the conserved nature of circRNA across different species in both animals and plants; for example, circRNA originating from genes like Imprinted in Prader-Willi syndrome (IPW), Plasmacytoma Variant Translocation 1 (PVT1) (Salzman et al., 2013), Homeodomain Interacting Protein Kinase 2 (HIPK2), HIPK3, and KIAA0182 (Jeck et al., 2013) are reported to be present in both mice and humans. The gene discussed is PVT1; the disease is Prader-Willi syndrome.