CCN2 and Hepatic fibrosis: Hepatic fibrosis assessed by Sirius Red staining of interstitial collagen (Figure 2B) was attenuated to near-baseline levels by i.p. administration of EVNorm over the last 2 weeks of the experiment and this was associated with reduced levels of CCl4-induced protein levels of αSMA, CCN2, or Col1a1 assessed by immunostaining (Figure 2C).