Specifically, the aim of the present study was to evaluate whether liraglutide and twincretin administration of a clinically translatable dose could mitigate mTBI-induced cognitive deficits, neuronal degeneration, and neuroinflammation, and to appraise which downstream cascade of GLP-1R/GIPR activation was primarily responsible for these neuroprotective actions. This evidence concerns the gene GLP1R and concussion.