ABCG2 and cancer: Figure 5 shows that the rich factor of the 3DG/2DG comparison is much higher than that of the 2DG/TCPS comparison. This is also the case for p-value. The shift from 2DG to 3DG induced regulation of a large number of pathways, including Central carbon metabolism in cancer (mmu05230), Mineral absorption (mmu04978), ABC transporters (mmu02010), Protein digestion and absorption (mmu04974), Aminoacyl-tRNA biosynthesis (mmu00970), Glycine, serine, and threonine metabolism (mmu00260), Biosynthesis of amino acids (mmu01230), and Tyrosine metabolism (mmu00350) (Figure 5B).