Nrf2 participates in infections by protozoan microorganisms in addition to those of Leishmania spp., such as those caused by Entamoeba histolytica, Cryptosporidium parvum, Plasmodium spp., and Toxoplasma gondii, all of which culminate in the modulation of Nrf2, and a diminished anti-inflammatory, and antioxidant profile (Morada et al., 2013; Aldaba-Muruato et al., 2017; Ramos et al., 2019; Xu et al., 2019). Here, NFE2L2 is linked to infection.