KLF9 and melanoma: Indeed, while mechanistically demonstrating that ablation of Klf9, a pro-oxidant transcriptional regulator, promotes metastases in a BrafV600E; Pten−/− GEMM of melanoma without affecting primary tumor growth, the authors also reasoned that Klf9 deficiency inhibits premalignant melanocytic hyperplasia in a BrafV600E-induced hyperplasia model (77).