Downregulating lncRNA XIST in BC tissues improved the viability of BC cells through repressed expression of PHLPP1 (a phosphatase-inhibiting AKT phosphorylation) via increased HDAC3 recruitment to the PHLPP1 promoter, which had a mediatory effect on upregulation of AKT phosphorylation with no mention of any role for the downregulated TSIX (28). Here, HDAC3 is linked to breast cancer.