CD274 and neoplasm: The triple-negative subtype was demonstrated in several studies to frequently express the programmed cell death-ligand 1 (PD-L1) (5, 6); there exist an overall immune system dysfunction and suppression throughout different BC subtypes due to the abundance of immune suppressive cells, namely, regulatory T cells (Tregs), and myeloid-derived suppressor cells (MDSCs), within the BC tumor microenvironment (7).