As previously suggested, a diagnosis of AIHA can be established in the presence of Hb <11 g/dL, no chemotherapy in the previous month, variable alteration of hemolytic markers (increased unconjugated bilirubin, elevated lactate dehydrogenase, consumption of haptoglobin, increased absolute reticulocyte counts), and the positivity of the direct antiglobulin test (DAT) (1, 33). The gene discussed is HP; the disease is autoimmune hemolytic anemia.