CTLA4 and autoimmune disease: Pathogenic mutations in genes involved in primary immunodeficiencies (TNFRSF6, CTLA4, STAT3, PIK3CD, CBL, ADAR1, LRBA, RAG1, and KRAS) were found in 40% of cases, and probable pathogenic variants in 16 genes not previously reported in autoimmune disease were detected in 25%.