Regarding prion uptake by villus epithelial cells, uptake by endocytosis of BSEPrPSc via 37 kDa/67 kDa laminin receptor has been observed in humanenterocytes46).Using high-resolution immunofluorescence and cryo-immunogold electron microscopy,Kujala et al detected PrP in large endosomes of enterocytes in thefollicle-associated epithelium and at much lower levels in M cells in the mice,which were inoculated with the brain homogenate from scrapie-affected mice.Immunolabeled PrP was also detected on plasma membranes of follicular dendriticcells (FDCs) in germinal centers of PP47). Here, PRNP is linked to scrapie.