BRCA1/2 mutations occur at scattered sites, and occur missense mutations, especially which will influence those situated in exons encoding domains that interact with BRCA1-binding proteins, such as BARD1, BRIP1 and PALB2, which (along with RAD51C, RAD51D and possibly RAP80 and FAM175A, encoding Abraxas) are also breast and/or ovarian cancer susceptibility genes (Foulkes, 2013). The gene discussed is BRIP1; the disease is ovarian cancer.