BRCA1 and breast cancer: There were about 7–10% BC patients with BRCA1/2 mutations and the rest were BRCA1/2 wild type, obtained from the cBioPortal website; among them, the proportion of BRCA1 &BRCA2 mutations was 3% (38/1094, TCGA: Provisional) & 4% (48/1094, TCGA Provisional) (or, 4%,45/1084 & 5%,54/1084, in TCGA: PanCancer Atlas, shown in Fig. S1A).